ABSTRACT
Uric acid can stimulate the synthesus of c-creative protien, and that might be one of the mechanisms underlying the endothelial dysfunction.several studies showed an independent link between UA and CRP suggest that chronic exposure to mild hyperuricemia may be a factor that contributes to micro inflammation and raised CRP in individual the essential hypertension. To inestigate the realtionship between the serum uric acid, C-RP, total cholesterol and endothelial dysfunction in patient with essential hyoertension. Twenty patients with essential hypertension and fifteen apparently healthy subjects matched for age and weight have been included in this study, uric and total cholesterol were determined by enzymatic methods, high senstivity C-reactive protien [HsCRP] enzyme immunoassyfor the quantitaive determination in human serum was used. The data obtained showed that the serum levels of uric acid, C-Reactive protiens and total cholesterol were significantly higher in patients with hyoertension than in healthy controls. The conclusion was that hyperuricemia in individuals with essential hypertension in associated with endothelial dysfunction. The hypothesis that uric acid plays a significant role in this alternation in humans